Organic letters

Palladium-Catalyzed sp 2 and sp 3 C–H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles

GW Wang, AX Zhou, JJ Wang, RB Hu, SD Yang

文献索引：Wu, Ge; Zhou, Jun; Zhang, Min; Hu, Peng; Su, Weiping Chemical Communications, 2012 , vol. 48, # 71 p. 8964 - 8966

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被引用次数: 30

摘要

The first Pd (II)-catalyzed C–H addition to isatins by direct sp 2/sp 3 C–H bond activation for the construction of 3-substituted-3-hydroxy-2-oxindoles is reported. The bidentate nitrogen ligands were found to promote this reaction. Specifically, the preliminary bioassay indicated