An improved method for the synthesis of. alpha.-diazo ketones

RL Danheiser, RF Miller, RG Brisbois…

文献索引：Danheiser, Rick L.; Miller, Raymond F.; Brisbois, Ronald G.; Park, Saung Z. Journal of Organic Chemistry, 1990 , vol. 55, # 6 p. 1959 - 1964

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被引用次数: 196

摘要

Harvard University, 1987. However, we have thus far been unable to achieve efficient diazo transfer to ketone enolates employing these conditions. For example, exposure of the lithium enolate of acetophenone to 1.2 equiv of PNBSA in THF at-78 OC for 15 min gave a- diazoacetophenone in only 21% yield.