The Journal of organic chemistry

Probing the importance of the hemilabile site of bis (phosphine) monoxide ligands in the copper-catalyzed addition of diethylzinc to N-phosphinoylimines: Discovery of …

I Bonnaventure, AB Charette

文献索引：Bonnaventure, Isabelle; Charette, Andre B. Journal of Organic Chemistry, 2008 , vol. 73, # 16 p. 6330 - 6340

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被引用次数: 82

摘要

The hemilabile ligand Me-DuPHOS (O) 2 has proven to be a successful ligand for the copper-catalyzed addition of diethylzinc to N-phosphinoylimines. The corresponding α-chiral amines were obtained in high yields (80− 98%) and enantiomeric ratios (19.0: 1 to 99.0: 1 er). Furthermore, this Cu• 2 catalytic system has been shown to be effective in the addition of diethylzinc to nitroalkenes and in the reduction of β, β-disubstituted vinyl phenyl sulfones. ...