Synthesis of. alpha.-methylene-. gamma.-butyrolactones: a structure-activity relationship study of their allergenic power

G Schlewer, JL Stampf, C Benezra

文献索引：Schlewer, Gilbert; Stampf, Jean-Luc; Benezra, Claude Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 1031 - 1038

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被引用次数: 76

摘要

Thirty-five a-methylene-y-butyrolactones have been prepared and their allergenic properties tested on the skin of guinea pigs experimentally sensitized to (a) alantolactone (l),(b) isoalantolactone (2), and (c) a-methylene-ybutyrolactone (3). The two first groups of animals cross-react to lactones containing 9 to 18 carbon atoms but not to smaller a-methylene-y- butyrolactones. Conversely, animals sensitized to a-methylene-y-butyrolactone react only ...