The Journal of organic chemistry

Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl-and ferrocenyldialkylphosphine ligands

NA Beare, JF Hartwig

文献索引：Beare, Neil A.; Hartwig, John F. Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 541 - 555

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被引用次数: 194

摘要

Palladium-catalyzed reactions of aryl bromides and chlorides with two common stabilized carbanions enolates of dialkyl malonates and alkyl cyanoesters are reported. An exploration of the scope of these reactions was conducted, and the processes were shown to occur in a general fashion. Using P (t-Bu) 3 (1), the pentaphenylferrocenyl ligand (Ph5C5) Fe (C5H4) P (t-Bu) 2 (2), or the adamantyl ligand (1-Ad) P (t-Bu) 2 (3), reactions of electron-poor and ...