Novel 3-hydroxy-2 (1H)-pyridinones. Synthesis, iron (III)-chelating properties and biological activity

M Streater, PD Taylor, RC Hider…

文献索引：Streater; Taylor; Hider; Porter Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1749 - 1755

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被引用次数: 118

摘要

The synthesis of a range of novel bidentate and hexadentate ligands containing the chelating moiety 3-hydroxy-2 (1H)-pyridinone is described. The pK, values of the ligands and the stability constants of their iron (II1) complexes have been determined. The stability constant of the iron (II1) complex of one of the hexadentate ligands is comparable to that of desferrioxamine B. The distribution coefficients of the ligands and their iron (II1) ...