Novel 3-hydroxy-2 (1H)-pyridinones. Synthesis, iron (III)-chelating properties and biological activity

M Streater, PD Taylor, RC Hider…

Index: Streater; Taylor; Hider; Porter Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1749 - 1755

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Citation Number: 118

Abstract

The synthesis of a range of novel bidentate and hexadentate ligands containing the chelating moiety 3-hydroxy-2 (1H)-pyridinone is described. The pK, values of the ligands and the stability constants of their iron (II1) complexes have been determined. The stability constant of the iron (II1) complex of one of the hexadentate ligands is comparable to that of desferrioxamine B. The distribution coefficients of the ligands and their iron (II1) ...