Synthesis and structure-activity studies of N, N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive …
NL Reddy, LY Hu, RE Cotter, JB Fischer…
文献索引：Reddy, N. Laxma; Hu, Lain-Yen; Cotter, Ronald E.; Fischer, James B.; Wong, Wen Jee; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 2 p. 260 - 267
Introduction TheN-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor, may play a pivotal role in many brain Excessive stimulation of NMDA receptors has been implicated in nerve cell death in stroke, brain, or spinal cord trauma and in some neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. 324 Compounds which specifically antagonize the actions of the neurotransmitter glutamate at ...
