Synthesis and structure-activity studies of N, N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive …

NL Reddy, LY Hu, RE Cotter, JB Fischer…

Index: Reddy, N. Laxma; Hu, Lain-Yen; Cotter, Ronald E.; Fischer, James B.; Wong, Wen Jee; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 2 p. 260 - 267

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Citation Number: 67

Abstract

Introduction TheN-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor, may play a pivotal role in many brain Excessive stimulation of NMDA receptors has been implicated in nerve cell death in stroke, brain, or spinal cord trauma and in some neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. 324 Compounds which specifically antagonize the actions of the neurotransmitter glutamate at ...