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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

TSAO analogs. Stereospecific synthesis and anti-HIV-1 activity of 1-[2', 5'-bis-O-(tert-butyldimethylsilyl)-. beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'', 2''-oxathiole-2'', …

MJ Perez-Perez, A San-Felix, J Balzarini…

文献索引：Journal of Medicinal Chemistry, , vol. 35, # 16 p. 2988 - 2995

全文：HTML全文

被引用次数: 95

摘要

... Chem., in press. Page 3. 2990 Journal of Medicinal Chemistry, 1992, Vol. 35, No. 16 P&ez-P&ez et al. Scheme 111 NH, ... (c) The I3C NMR showed no changes in the chemical shifts of C-2 and C-4 with respect to those observed for 8a, used as starting material. ...

碘乙烷结构式

(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine结构式

(2',5'-bis-O-(t...

~77%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-3-ethyl-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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1,2-O-(异丙亚基)-ALPHA-D-赤式-呋喃戊-3-酮糖苯甲酸酯结构式

1,2-O-(异丙亚基)-AL...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-3-ethyl-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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(1-(β-D-ribofuranosyl)thymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide)结构式

(1-(β-D-ribofur...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-3-ethyl-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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((3aR,5R,6R,6aR)-6-cyano-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate结构式

((3aR,5R,6R,6aR...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-3-ethyl-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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1-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-O-mesyl-β-D-ribofuranosyl)thymine结构式

1-(2'-O-acetyl-...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-3-ethyl-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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[(6R,8R,9R)-9-acetyloxy-4-amino-8-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate结构式

[(6R,8R,9R)-9-a...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-3-ethyl-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine结构式

(2',5'-bis-O-(t...

1-溴-3-甲基-2-丁烯结构式

1-溴-3-甲基-2-丁烯

~67%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methyl-3-(3-methylbut-2-enyl)pyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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1,2-O-(异丙亚基)-ALPHA-D-赤式-呋喃戊-3-酮糖苯甲酸酯结构式

1,2-O-(异丙亚基)-AL...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methyl-3-(3-methylbut-2-enyl)pyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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(1-(β-D-ribofuranosyl)thymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide)结构式

(1-(β-D-ribofur...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methyl-3-(3-methylbut-2-enyl)pyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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((3aR,5R,6R,6aR)-6-cyano-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate结构式

((3aR,5R,6R,6aR...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methyl-3-(3-methylbut-2-enyl)pyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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1-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-O-mesyl-β-D-ribofuranosyl)thymine结构式

1-(2'-O-acetyl-...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methyl-3-(3-methylbut-2-enyl)pyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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[(6R,8R,9R)-9-acetyloxy-4-amino-8-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate结构式

[(6R,8R,9R)-9-a...

~%

1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methyl-3-(3-methylbut-2-enyl)pyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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1-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-O-mesyl-β-D-ribofuranosyl)thymine结构式

1-(2'-O-acetyl-...

~65%

[(6R,8R,9R)-9-acetyloxy-4-amino-8-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate结构式

[(6R,8R,9R)-9-a...

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1,2-O-(异丙亚基)-ALPHA-D-赤式-呋喃戊-3-酮糖苯甲酸酯结构式

1,2-O-(异丙亚基)-AL...

~%

[(6R,8R,9R)-9-acetyloxy-4-amino-8-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate结构式

[(6R,8R,9R)-9-a...

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((3aR,5R,6R,6aR)-6-cyano-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate结构式

((3aR,5R,6R,6aR...

~%

[(6R,8R,9R)-9-acetyloxy-4-amino-8-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate结构式

[(6R,8R,9R)-9-a...

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