Synlett

Synthesis of DNA-interactive pyrrolo [2, 1-c][1, 4] benzodiazepines by employing polymer-supported reagents: Preparation of DC-81

A Kamal, KL Reddy, V Devaiah, N Shankaraiah

文献索引：Kamal, Ahmed; Reddy, K. Laxma; Devaiah; Shankaraiah Synlett, 2004 , # 14 p. 2533 - 2536

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被引用次数: 40

摘要

Abstract Polymer-supported reagents have been utilized for the generation of combinatorial library of substituted pyrrolo [2, 1-c][1, 4] benzodiazepine derivatives that provides a clean and efficient preparation and does not require conventional purification techniques like chromatography. This methodology involves intra molecular aza-Wittig reaction and has been extended for the synthesis of the natural product DC-81 in good overall yields.