Benzyl DC-81

• 常用名: Benzyl DC-81
• 英文名: Benzyl DC-81
• CAS号: 127810-79-1
• 分子量: 336.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₀N₂O₃
• 熔点: N/A
• 闪点: N/A

Benzyl DC-81用途

苄基DC-81(化合物6a)是一种对A375和MCF-7细胞具有抗增殖活性的抗癌剂[1]。

Benzyl DC-81名称

• 英文名: (11aS)-8-(benzyloxy)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Benzyl DC-81生物活性

• 描述: 苄基DC-81(化合物6a)是一种对A375和MCF-7细胞具有抗增殖活性的抗癌剂[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Adiyala PR, et al. Development of pyrrolo[2,1-c][1,4]benzodiazepine β-glucoside prodrugs for selective therapy of cancer. Bioorg Chem. 2018 Feb;76:288-293.

Benzyl DC-81物理化学性质

• 分子式: C₂₀H₂₀N₂O₃
• 分子量: 336.38
• 精确质量: 336.14700
• PSA: 51.13000
• LogP: 2.96820
• InChIKey: PXXBSLZVZRNTAD-HNNXBMFYSA-N
• SMILES: COc1cc2c(cc1OCc1ccccc1)N=CC1CCCN1C2=O

Benzyl DC-81靶点实验

查看更多实验

实验名称：Change in thermal denaturation temperature determined from calf thymus DNA after incu... 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL821235

实验名称：Concentration required to inhibit A2780cisR cell growth when compared with control af... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL618328

实验名称：Change in thermal denaturation temperature determined from calf thymus DNA after incu... 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL821234

实验名称：Concentration required to inhibit CH1 tumor cell growth when compared with control af... 来源：ChEMBL 靶标：CH1 External Id：CHEMBL657458

实验名称：Tested for cytotoxicity against L1210 Leukemia cell 来源：ChEMBL 靶标：L1210 External Id：CHEMBL708791

实验名称：Tested for cytotoxicity against ADJ/PC6 plasmacytoma 来源：ChEMBL 靶标：N/A External Id：CHEMBL620515

实验名称：Resistance factor was determined as IC50 cisplatin-resistant/parent for human A2780 o... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL618567

实验名称：Tested for thermal denaturation against CT-DNA at 0 hours 来源：ChEMBL 靶标：Calf thymus DNA External Id：CHEMBL666204

实验名称：Tested for thermal denaturation against CT-DNA at 4 hours 来源：ChEMBL 靶标：Calf thymus DNA External Id：CHEMBL666205

实验名称：Concentration required to inhibit SKOV-3 cell growth when compared with control after... 来源：ChEMBL 靶标：SK-OV-3 External Id：CHEMBL805525

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Benzyl DC-81英文别名

• .Bn ether of DC-81
• .DC-81 benzyl ether
• .8-benzyl DC-81
• .8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepin-5-one
• .(11aS)-8-benzyloxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
• (11aS)-8-benzyloxy-7-methoxy-1,2,3-trihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one