前往化源商城

Synthesis of. alpha.-hydroxy ketones by direct, low-temperature, in situ nucleophilic acylation of aldehydes and ketones by acyllithium reagents

D Seyferth, RM Weinstein, RC Hui…

文献索引:Seyferth, Dietmar; Weinstein, Robert M.; Hui, Richard C.; Wang, Wei-Liang; Archer, Colin M. Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5620 - 5629

全文:HTML全文

被引用次数: 31

摘要

The reaction of n-, see, and tert-butyllithium with CO at atmospheric pressure at-110 and- 135 OC in the appropriate solvent system in the presence of ketones and aldehydes generates the acyllithium, RC (O) Li, which rea& with the carbonyl compound to give the a- hydroxy ketone, generally in good yield. Reactions with aldehydes are limited in scope, working well with the t-BuLi-derived acyllithium reagents, but not with n-BuC (0) Li.

 相关合成线路

~83%

查看详情

~25%

详细 查看详情

~93%

查看详情

~89%

查看详情

~86%

查看详情

~49%

查看详情

~21%

查看详情

~%

详细 查看详情

~18%

查看详情

~%

详细 查看详情

~17%

查看详情

~63%

详细 查看详情

~90%

详细 查看详情

~%

详细 查看详情

~%

详细 查看详情

~%

详细 查看详情

~1%

详细 查看详情

~59%

查看详情

~6%

详细 查看详情