A scalable method for regioselective 3-acylation of 2-substituted indoles under basic conditions

H Johansson, A Urruticoechea, I Larsen…

文献索引：Coffman, Keith C.; Palazzo, Teresa A.; Hartley, Timothy P.; Fettinger, James C.; Tantillo, Dean J.; Kurth, Mark J. Organic Letters, 2013 , vol. 15, # 8 p. 2062 - 2065

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被引用次数: 8

摘要

... J. Org. ... Using indole 5 we screened acylation conditions with chloroacetyl chloride 6 and a series of organic bases with basicity ranging from moderate to ... procedure: indole (1 mmol), DCE (3 mL/mmol indole) and DBU (1.2 equiv) were mixed and heated to 90 °C under argon ...