J. Med. Chem

Sui Xiong Cai,*, Jin-Cheng Huang, Stephen A. Espitia, Minhtam Tran, Victor I. Ilyin, Jon E. Hawkinson

RM Woodward, E Weber, JFW Keana

文献索引：Cai, Sui Xiong; Huang, Jin-Cheng; Espitia, Stephen A.; Tran, Minhtam; Ilyin, Victor I.; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F.W. Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3679 - 3686

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被引用次数: 1

摘要

A group of 5-aza-7-substituted-1, 4-dihydroquinoxaline-2, 3-diones (QXs) and the corresponding 5-(N-oxyaza)-7-substituted QXs were prepared and evaluated as antagonists of ionotropic glutamate receptors. The in vitro potency of these QXs was determined by inhibition of [3H]-5, 7-dichlorokynurenic acid ([3H] DCKA) binding to N-methyl-D-aspartate (NMDA)/glycine receptors,[3H]-(S)-R-amino-3-hydroxy-5-methyl-4-isoxazolepropionic ...