A novel class of inhibitors for steroid 5α-Reductase: synthesis and evaluation of umbelliferone derivatives
G Fan, W Mar, MK Park, EW Choi, K Kim…
文献索引：Fan, Gao-jun; Mar, Woongchon; Park, Man Ki; Wook Choi, Eun; Kim, Kinam; Kim, Sanghee Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 17 p. 2361 - 2363
A series of umbelliferone derivatives was prepared and their 5α-reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5α-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5α- reductase type 1. The preliminary structure–activity relationship was described to ...
