Since the original report by the group of Kulinkovich in 1989, 1 the transformations mediated by excess amounts of Grignard reagents in the presence of alkoxytitanium(IV) species of the type XTi(OiPr) 3 (X = Cl, OiPr) have emerged as a family of powerful reactions with remarkably broad scope. 2 In particular, the Kulinkovich–de Meijere cyclopropanation of carboxylic amides can now be considered as the method of choice for the synthesis of tertiary ...
