Ligandfree CuTC-catalyzed N-arylation of amides, anilines and 4-aminoantipyrine: synthesis of N-arylacrylamides, 4-amido-N-phenylbenzamides and 4-amino (N- …
N-Arylamides and diarylamines are important synthetic building blocks that are prevalent in many bioactive compounds and medicinal agents, and have important roles in organic synthesis and biological and pharmaceutical research.[1] As a more efficient and facile method, the transition metal-catalyzed coupling reaction of aryl halides or pseudo halides and amides or anilines has been attractive for many years.[2] In particular, the palladium-[ ...