Sébastien Foulquier,Evangelos P. Daskalopoulos,Gentian Lluri,Kevin C. M. Hermans,Arjun Deb,W. Matthijs Blankesteijn,Martin C. Michel,ASSOCIATE EDITOR,Sébastien Foulquier,Evangelos P. Daskalopoulos,Gentian Lluri,Kevin C. M. Hermans,Arjun Deb,W. Matthijs Blankesteijn,Sébastien Foulquier,Evangelos P. Daskalopoulos,Gentian Lluri,Kevin C. M. Hermans,Arjun Deb,W. Matthijs Blankesteijn
文献索引:10.1124/pr.117.013896
全文:HTML全文
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by multiple signaling molecules. WNT signaling is critically important for developmental processes, including cell proliferation, differentiation and tissue patterning. Little WNT signaling activity is present in the cardiovascular system of healthy adults, but reactivation of the pathway is observed in many pathologies of heart and blood vessels. The high prevalence of these pathologies and their significant contribution to human disease burden has raised interest in WNT signaling as a potential target for therapeutic intervention. In this review, we first will focus on the constituents of the pathway and their regulation and the different signaling routes. Subsequently, the role of WNT signaling in cardiovascular development is addressed, followed by a detailed discussion of its involvement in vascular and cardiac disease. After highlighting the crosstalk between WNT, transforming growth factor-β and angiotensin II signaling, and the emerging role of WNT signaling in the regulation of stem cells, we provide an overview of drugs targeting the pathway at different levels. From the combined studies we conclude that, despite the sometimes conflicting experimental data, a general picture is emerging that excessive stimulation of WNT signaling adversely affects cardiovascular pathology. The rapidly increasing collection of drugs interfering at different levels of WNT signaling will allow the evaluation of therapeutic interventions in the pathway in relevant animal models of cardiovascular diseases and eventually in patients in the near future, translating the outcomes of the many preclinical studies into a clinically relevant context.
Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain...
2018-04-01 [10.1124/pr.117.014647] |
Interindividual Differences in Caffeine Metabolism and Facto...
2018-04-01 [10.1124/pr.117.014407] |
Transcription Factor NRF2 as a Therapeutic Target for Chroni...
2018-04-01 [10.1124/pr.117.014753] |
Etiology and Pharmacology of Neuropathic Pain
2018-04-01 [10.1124/pr.117.014399] |
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Cli...
2018-04-01 [10.1124/pr.117.014381] |
首页 |
期刊大全 |
MSDS查询 |
化工产品分类 |
生物活性化合物 |
关于我们 |
免责声明:知识产权问题请联系 service1@chemsrc.com
Copyright © 2024 ChemSrc All Rights Reserved