Phase-transfer-catalyzed Michaelis-Becker reaction

KM Kem, NV Nguyen, DJ Cross

文献索引：Kem, Kenneth M.; Nguyen, Nghi V.; Cross, Dennis J. Journal of Organic Chemistry, 1981 , vol. 46, p. 5188 - 5192

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被引用次数: 31

摘要

Dialkyl hydrogen phosphonates or dialkylphosphine oxides are conveniently and efficiently alkylated by alkyl chlorides to produce dialkyl alkylphosphonates or trialkylphosphine oxides, respectively, by aqueous sodium hydroxide in a liquid-liquid phase-transfer- catalyzed reaction. Despite the hydrolytic instability of dialkyl hydrogen phosphonates, their reaction with chloroacetamides in the two-phase system can provide dialkyl ( ...