The Journal of organic chemistry

One-pot copper (I)-catalyzed synthesis of 3, 5-disubstituted isoxazoles

TV Hansen, P Wu, VV Fokin

文献索引：Hansen, Trond V.; Wu, Peng; Fokin, Valery V. Journal of Organic Chemistry, 2005 , vol. 70, # 19 p. 7761 - 7764

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被引用次数: 170

摘要

3, 5-Disubstituted isoxazoles are obtained in good yields by a convenient one-pot, three- step procedure utilizing a regioselective copper (I)-catalyzed cycloaddition reaction between in situ generated nitrile oxides and terminal acetylenes. Most functional groups do not interfere with the reaction, which can be performed in aqueous solvents without protection from oxygen. Since all reagents are used in stoichiometric amounts, formation of ...