Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4, 5-dihydro-6-[4-(H-imidazol-1-yl) phenyl]-3 (2H)-pyridazinones: a new class of positive …

I Sircar, BL Duell, G Bobowski, JA Bristol…

文献索引：Sircar, Ila; Duell, Bradley L.; Bobowski, George; Bristol, James A.; Evans, Dale B. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1405 - 1413

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被引用次数: 106

摘要

A series of 4, 5-dihydrc-6-[4-(1H-imidazol-l-yl) phenyl]-3 (! 2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity. Most members of this series produced dose-related increases in myocardial contractility that were associated with relatively minor increases in heart rate and decreases in systemic arterial blood pressure. Introduction of a methyl substituent at the 5-position of 1 (CI-914) produced the ...