Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines

F Johnson, KMR Pillai, AP Grollman…

文献索引：Johnson; Pillai; Grollman; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 954 - 958

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被引用次数: 47

摘要

1 ously.'The general method gives good yields and was used for the synthesis of a series of the related pyrimidine derivatives (7, 8, and 10-14). A modified variation of this procedure was used for the synthesis of the cytosine propenal compound 2. Compounds 12 and 13 were prepared by substituting cyanoacetylene or l-butyn-3-one, respectively, for 2-propynal in the reaction. The reduction product (15) of 1 was prepared by using sodium ...