The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase
…, JD Artz, WH Pearson, MA Marletta
文献索引：Hering, Kirk W.; Artz, Jennifer D.; Pearson, William H.; Marletta, Michael A. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 3 p. 618 - 621
Soluble guanylate cyclase (sGC) is highly activated in the presence of both YC-1 (1-benzyl- 3-(5′-hydroxymethyl-2′-furyl)-indazole) and CO. In this report, the design, synthesis, and activity (ie, sGC activation) of photolabile analogues of 3-(5′-hydroxymethyl-2′-furyl)-1- benzylindazole (YC-1) are presented. Initial results with 6-azido-3-(5′-hydroxymethyl-2′- furyl)-1-benzylindazole led to the synthesis of a tritium-labeled analogue. When ...
