The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase

…, JD Artz, WH Pearson, MA Marletta

Index: Hering, Kirk W.; Artz, Jennifer D.; Pearson, William H.; Marletta, Michael A. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 3 p. 618 - 621

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Citation Number: 25

Abstract

Soluble guanylate cyclase (sGC) is highly activated in the presence of both YC-1 (1-benzyl- 3-(5′-hydroxymethyl-2′-furyl)-indazole) and CO. In this report, the design, synthesis, and activity (ie, sGC activation) of photolabile analogues of 3-(5′-hydroxymethyl-2′-furyl)-1- benzylindazole (YC-1) are presented. Initial results with 6-azido-3-(5′-hydroxymethyl-2′- furyl)-1-benzylindazole led to the synthesis of a tritium-labeled analogue. When ...