Chiral selector with multiple hydrogen-bonding sites in a macrocyclic cavity

T Ema, D Tanida, K Sugita, T Sakai, K Miyazawa…

文献索引：Ema, Tadashi; Tanida, Daisuke; Sugita, Kyoko; Sakai, Takashi; Miyazawa, Ken-Ichiro; Ohnishi, Atsushi Organic Letters, 2008 , vol. 10, # 12 p. 2365 - 2368

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被引用次数: 23

摘要

Chiral macrocycles with the hydrogen bond donor/acceptor sites in the cavity were synthesized and covalently bonded to silica gel to give chiral stationary phases (CSPs), which showed excellent abilities to resolve various chiral compounds, such as benzoin and Co (acac) 3, in HPLC. Various organic solvents could be used as the mobile phase to optimize the resolution efficiency of CSPs, and in some cases, even MeCN, MeOH, and ...