Simple, Stable, and Easily Accessible Well??Defined CuCF3 Aromatic Trifluoromethylating Agents

OA Tomashenko, EC Escudero??Adán…

文献索引：Tomashenko, Olesya A.; Escudero-Adan, Eduardo C.; Martinez Belmonte, Marta; Grushin, Vladimir V. Angewandte Chemie - International Edition, 2011 , vol. 50, # 33 p. 7655 - 7659

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被引用次数: 177

摘要

Trifluoromethylated aromatic compounds are widely used as active ingredients of numerous modern pharmaceuticals and agrochemicals (Scheme 1).[1, 2] Currently, CF3-bearing aromatic building blocks are made by a Swarts-type process involving exhaustive chlorination of a methyl group on the ring and subsequent Cl/F exchange on the resultant ArCCl3 with HF.[3] This process deals with hazardous materials and generates large ...