Chinese Chemical Letters

Design, synthesis and biological evaluation of new rhodacyanine analogues as potential antitumor agents

YX Li, X Zhai, WK Liao, WF Zhu, Y He, P Gong

文献索引：Li, Yang Xiong; Zhai, Xin; Liao, Wei Ke; Zhu, Wu Fu; He, Ying; Gong, Ping Chinese Chemical Letters, 2012 , vol. 23, # 4 p. 415 - 418

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被引用次数: 4

摘要

In an attempt to develop potent antitumor agents, new rhodacyanine analogues containing the pyridinium ring (5a–5h), the isoquinolinium ring (6a–6c) and the quinolinium ring (7a– 7e) linked to the rhodanine ring via N–N covalent bond were designed, synthesized and evaluated for antitumor activity against human lung cancer cell line (H460) by MTT assay in vitro. Most of the tested compounds showed enhanced antitumor activity with IC50 values ...