Imidazo [1, 2-c] quinazolines with lipid peroxidation inhibitory effect

…, G Farsang, GG Ferenczy, G Tárkányi…

文献索引：Domany, Gyoergy; Gizur, Tibor; Gere, Aniko; Takacs-Novak, Krisztina; Farsang, Gyoergy; Ferenczy, Gyoergy G.; Tarkanyi, Gabor; Demeter, Maria European Journal of Medicinal Chemistry, 1998 , vol. 33, # 3 p. 181 - 187

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被引用次数: 16

摘要

A series of imidazo [1, 2-c] quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe2+-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent ...