Approaches to protection against nerve agent poisoning.(Naphthylvinyl) pyridine derivatives as potential antidotes

…, TR Henderson, TCP Chang, K Takahashi…

文献索引：Gray, Allan P.; Platz, Robert D.; Henderson, Theresa R.; Chang, Timothy C. P.; Takahashi, Kazuyuki; Dretchen, Kenneth L. Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 807 - 814

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被引用次数: 20

摘要

Analogues of the potent inhibitor of choline acetyltransferase (CAT)(E)-4-(l-naphthylvinyl) pyridine methiodide were synthesized and evaluated for their ability to inhibit CAT and protect against nerve agent intoxication. Several compounds, notably (E)-l-(2-hydroxyethyl)- (l-naphthylvinyl) pyridinium bromide (3),(E)-l-methyl-4-(1-naphthylviny1)-1, 2, 3, 64etrahydropyridine hydrochloride (22), and (E)-l-methyl-4-(1-naphthylviny1) piperidine ...