Discovery of the novel antithrombotic agent 5-chloro-N-({(5 S)-2-oxo-3-[4-(3-oxomorpholin-4-yl) phenyl]-1, 3-oxazolidin-5-yl} methyl) thiophene-2-carboxamide (BAY …

…, KH Schlemmer, P Reinemer…

文献索引：Aitken, R. Alan; Bibby, Michael C.; Bielefeldt, Florian; Double, John A.; Laws, Andrea L.; Mathieu, Anne-Laure; Ritchie, Robert B.; Wilson, David W. J. Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 405 - 411

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被引用次数: 351

摘要

... oxazolidinone ring was essential [IC 50 value of 0.7 nM for (S)-enantiomer 8 5 vs 2.3 μM for (R)-enantiomer 16 ... activity was obtained for the morpholinone series than for 11, which correlated well with the lower concentration required to double the PT ... 5, 0.40 c, 0.30 c, 0.9 c, 60 d, 1.3 ...