In vivo studies of dialkynoyl analogues of DOTAP demonstrate improved gene transfer efficiency of cationic liposomes in mouse lung

S Fletcher, A Ahmad, E Perouzel, A Heron…

文献索引：Fletcher, Steven; Ahmad, Ayesha; Perouzel, Eric; Heron, Andrew; Miller, Andrew D.; Jorgensen, Michael R. Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 349 - 357

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被引用次数: 38

摘要

A novel set of dialkynoyl analogues of the cationic, gene delivery lipid DOTAP (1) was synthesized. Structure-activity studies demonstrate that replacement of the cis-double bonds of DOTAP with triple bonds in varying positions alters both the physical properties of the resultant cationic liposome-DNA complexes and their biological functionalities, both in vitro and in vivo. Particularly, in vivo studies demonstrate that pDNA transfection of mouse lung ...