Green and facile synthesis of 1, 4-disubstituted 1, 2, 3-triazoles via a click reaction of α-bromo ketones,[bmim] n3 and terminal acetylenes

A Fazeli, HA Oskooie, YS Beheshtiha…

文献索引：Heravi, Majid M.; Fazeli, Azadeh; Oskooie, Hossein A.; Beheshtiha, Yahya S.; Valizadeh, Hassan Synlett, 2012 , vol. 23, # 20 p. 2927 - 2930

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被引用次数: 10

摘要

An efficient and green one pot method is reported for regioselective synthesis of 1, 4- disubstituted 1, 2, 3-triazoles. In this method, β.-ketoazides are generated via in situ reaction between α-bromo ketones and 1-butyl-3-methylimidazolium azide [bmim] N3 in aqueous ethanol and reacted with terminal acetylenes using Cu-CuSO4 at room temperature to afford 1, 4-disubstituted 1, 2, 3-triazoles.