Endothelin receptor antagonists: synthesis and structure–activity relationships of substituted benzothiazine-1, 1-dioxides

…, JJ Edmunds, AM Bunker, S Haleen, J Bryant…

文献索引：Berryman; Edmunds; Bunker; Haleen; Bryant; Welch; Doherty Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1447 - 1456

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被引用次数: 18

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The development of benzothiazine-1,1-dioxide derivatives as a new structural class of potent endothelin receptor antagonists is described. Structure–activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ET A receptor subtype. ... In our continuing efforts to design ...