Abstract Reaction between 3, 4, 5-triamino-1, 2, 6-thiadiazine 1, 1-dioxides and aldehydes, in acetic acid or DMF, under anhydrous conditions, leads to a mixture of imidazo [4, 5-c]-and pyrazino [2, 3-c]-1, 2, 6-thiadiazine derivatives. The ratio of both compounds depends on the nature of the aldehydes used. The same reaction, in the absence of solvent, affords, only pyrazinothiadiazine derivatives. The uv, 1 H-and 13 C-nmr data of the new compounds ...