Design, solvent free synthesis, and antimicrobial evaluation of 1, 4 dihydropyridines

…, A Rajack, MT Ramji, C Praveen, KA Lakshmi

文献索引：Murthy; Rajack, Abdul; Taraka Ramji; Jeson Babu; Praveen, Ch.; Aruna Lakshmi Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 6016 - 6023

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被引用次数: 26

摘要

Here in, we report the usage of cellulose sulfuric acid as a heterogeneous eco friendly catalyst for the synthesis of 1, 4 dihydropyridines under solvent free conditions via Hantzsch three component reaction of an aldehyde, ethyl acetoacetate and ammonium acetate at 100° C for 2–5h. In silico studies were performed on twenty two possible 1, 4 dihydropyridines (DHPs) analogues against K+ channel receptor (KcsA). In order to ...