Tetrahedron

Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions

E Riva, S Gagliardi, M Martinelli, D Passarella, D Vigo…

文献索引：Riva; Gagliardi; Martinelli; Passarella; Vigo; Rencurosi Tetrahedron, 2010 , vol. 66, # 17 p. 3242 - 3247

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被引用次数: 50

摘要

This contribution details how a continuous flow reactor was used to react carbonyl compounds with Grignard reagents at room temperature in an efficient and safe manner. Flow rate, residence time and temperature were optimized for the preparation of a small collection of secondary and tertiary alcohols. Excellent yields and general applicability were observed using the set-up protocol. The procedure was also applied for the preparation of ...