The Journal of organic chemistry

Use of Fluoroform as a Source of Difluorocarbene in the Synthesis of Difluoromethoxy-and Difluorothiomethoxyarenes

CS Thomoson, WR Dolbier Jr

文献索引：Thomoson, Charles S.; Dolbier, William R. Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8904 - 8908

全文：HTML全文

被引用次数: 40

摘要

Fluoroform, CHF3, a non-ozone-depleting, nontoxic, and inexpensive gas can be used as a difluorocarbene source in a process for the conversion of phenols and thiophenols to their difluoromethoxy and difluorothiomethoxy derivatives. The reactions are carried out at moderate temperatures and atmospheric pressure, using potassium hydroxide as base in a two-phase (water/dioxane or water/acetonitrile) process to provide moderate to good ...