The Journal of Organic Chemistry

Oxidation of fluoroalkyl-substituted carbinols by the Dess-Martin reagent

RJ Linderman, DM Graves

文献索引：Linderman, Russell J.; Graves, David M. Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 661 - 668

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被引用次数: 132

摘要

During our initial investigations into this problem, we had two goals in mind, an oxidation procedure, which would occur under mild reaction conditions without requiring a large excess (10-15 equiv) of oxidant, and a reproducible procedure, which would be applicable to a variety of functionalized fluoroalkyl-substituted carbinols. Given the potential application of this chemistry to the synthesis of enzyme inhibitors, we chose to survey oxidants that ...