Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1, 3, 4-oxadiazoles

…, A Ahadian, P Navabi, V Zanganeh, A Shafiee

文献索引：Zarghi, Afshin; Tabatabai, Sayyed A.; Faizi, Mehrdad; Ahadian, Avideh; Navabi, Parisa; Zanganeh, Vahideh; Shafiee, Abbas Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1863 - 1865

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被引用次数: 186

摘要

A series of new 2-substituted-5-(2-benzyloxyphenyl)-1, 3, 4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism.