Synthesis and anticancer activity of benzyloxybenzaldehyde derivatives against HL-60 cells

CF Lin, JS Yang, CY Chang, SC Kuo, MR Lee…

文献索引：Lin, Chin-Fen; Yang, Jai-Sing; Chang, Chiung-Yun; Kuo, Sheng-Chu; Lee, Miau-Rong; Huang, Li-Jiau Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1537 - 1544

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被引用次数: 50

摘要

A series of benzyloxybenzaldehyde derivatives were prepared and tested against the HL-60 cell line for anticancer activity. Preliminary structure–activity relationships were established. It was discovered that 2-(benzyloxy) benzaldehyde (17), 2-(benzyloxy)-4- methoxybenzaldehyde (26), 2-(benzyloxy)-5-methoxybenzaldehyde (27), 2-(benzyloxy)-5- chlorobenzaldehyde (28), 2-[(3-methoxybenzyl) oxy] benzaldehyde (29), 2-[(2- ...