Synthesis and biological activity of 2-(bis ((1, 3, 4-oxadiazolyl/1, 3, 4-thiadiazolyl) methylthio) methylene) malononitriles

V Padmavathi, GD Reddy, SN Reddy…

文献索引：Padmavathi; Dinneswara Reddy; Nagi Reddy; Mahesh European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1367 - 1373

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被引用次数: 29

摘要

The reactivity of ketene dithiolates in the presence of different equivalents of sodium ethoxide was studied. 2-(Bis ((5-aryl-1, 3, 4-oxadiazol-2-yl) methylthio) methylene) malononitriles 5 and 2-(bis ((5-aryl-1, 3, 4-thiadiazol-2-yl) methylthio) methylene) malononitriles 6 were prepared by the reaction of malononitrile with carbon disulfide and 5- aryl-2-(chloromethyl)-1, 3, 4-oxadiazoles 3/5-aryl-2-(chloromethyl)-1, 3, 4-thiadiazoles 4. ...