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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Antiallergy agents. 1. Substituted 1, 8-naphthyridin-2 (1H)-ones as inhibitors of SRS-A release

…, JJ Kaminski, WC Tom, JF Lee, SC Wong…

文献索引：Sherlock, Margaret H.; Kaminski, James J.; Tom, Wing C.; Lee, Joe F.; Wong, Shing-Chun; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2108 - 2121

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被引用次数: 68

摘要

Scheme I). The required nicotinic acids and esters described in Table I, and the substituted amines described in the experimental section were either commercially available or their method of preparation has been described previo~ sly.~*-~~ The substituted pyridines (3) and congeners described in Table I1 were prepared by the procedures described by Kermack and Weatherhead24 or Nantka-N amir~ ky,~~ respectively. Following the ...

2-氯烟酸结构式

苄胺结构式

~93%

2-(苄基氨基)烟酸结构式

2-(苄基氨基)烟酸

乙酸酐结构式

1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

1-phenyl-4-prop...

~50%

1-Phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one结构式

1-Phenyl-3-(2-p...

环已乙酸乙酯结构式

环已乙酸乙酯

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~28%

3-cyclohexyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-cyclohexyl-4-...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

3-cyclohexyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-cyclohexyl-4-...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

3-cyclohexyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-cyclohexyl-4-...

2-氯烟酸结构式

4-正丁基苯胺结构式

4-正丁基苯胺

~97%

Butanixin结构式

己酸乙酯结构式

methyl 3-anilinopyrazine-2-carboxylate结构式

methyl 3-anilin...

~65%

7-butyl-8-hydroxy-5-phenylpyrido[2,3-b]pyrazin-6-one结构式

7-butyl-8-hydro...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

4-hydroxy-1-phenyl-3-(4-phenylbutyl)-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

4-hydroxy-1-phenyl-3-(4-phenylbutyl)-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

己酸乙酯结构式

methyl 2-((2,6-dimethylphenyl)amino)nicotinate结构式

methyl 2-((2,6-...

~61%

3-butyl-1-(2,6-dimethylphenyl)-4-hydroxy-1,8-naphthyridin-2-one结构式

3-butyl-1-(2,6-...

2-氯烟酸结构式

~%

3-butyl-1-(2,6-dimethylphenyl)-4-hydroxy-1,8-naphthyridin-2-one结构式

3-butyl-1-(2,6-...

甲尼辛结构式

~%

3-butyl-1-(2,6-dimethylphenyl)-4-hydroxy-1,8-naphthyridin-2-one结构式

3-butyl-1-(2,6-...

2,6-二甲基苯胺结构式

2,6-二甲基苯胺

~%

3-butyl-1-(2,6-dimethylphenyl)-4-hydroxy-1,8-naphthyridin-2-one结构式

3-butyl-1-(2,6-...

cyanomethyl 2-(3-methylthiophenylamino)nicotinate结构式

cyanomethyl 2-(...

~96%

methyl 2-(3-methylsulfanylanilino)pyridine-3-carboxylate结构式

methyl 2-(3-met...

2-氯烟酸结构式

~%

methyl 2-(3-methylsulfanylanilino)pyridine-3-carboxylate结构式

methyl 2-(3-met...

3-氨基茴香硫醚结构式

3-氨基茴香硫醚

~%

methyl 2-(3-methylsulfanylanilino)pyridine-3-carboxylate结构式

methyl 2-(3-met...

2-(3-Methylsulfanyl-phenylamino)-nicotinic acid结构式

2-(3-Methylsulf...

~%

methyl 2-(3-methylsulfanylanilino)pyridine-3-carboxylate结构式

methyl 2-(3-met...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~92%

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

2-氯烟酸结构式

N,N-二甲基乙二胺结构式

N,N-二甲基乙二胺

~58%

2-{[2-(Dimethylamino)ethyl]amino}nicotinic acid结构式

2-{[2-(Dimethyl...

2-氯烟酸结构式

5-氨基茚满结构式

~77%

2-(5-indanamino)-3-pyridine carboxylic acid结构式

2-(5-indanamino...

未登录结构式

~54%

4-hydroxy-3-(3-hydroxybutyl)-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-3-(3-...

乙酰丙酸乙酯结构式

乙酰丙酸乙酯

~%

4-hydroxy-3-(3-hydroxybutyl)-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-3-(3-...

ethyl 5,5-(ethylenedioxy)levulinate结构式

ethyl 5,5-(ethy...

~%

4-hydroxy-3-(3-hydroxybutyl)-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-3-(3-...

1-phenyl-3-[3,3-(ethylenedioxy)butyl]-4-hydroxy-1,8-naphthyridin-2(1H)-one结构式

1-phenyl-3-[3,3...

~%

4-hydroxy-3-(3-hydroxybutyl)-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-3-(3-...

1-Phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one结构式

1-Phenyl-3-(2-p...

~90%

3-烯丙基-4-羟基-1-苯基-1,8-萘啶-2(1H)-酮结构式

3-烯丙基-4-羟基-1-苯基...

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

~24%

3-butyl-1-phenyl-4-prop-2-ynoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

3-butyl-1-phenyl-4-prop-2-ynoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~%

3-butyl-1-phenyl-4-prop-2-ynoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

3-butyl-1-phenyl-4-prop-2-ynoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

methyl 2-(N-phenylhexanamido)nicotinate结构式

methyl 2-(N-phe...

~%

3-butyl-1-phenyl-4-prop-2-ynoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

~60%

3-butyl-4-ethoxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-ethox...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

3-butyl-4-ethoxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-ethox...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~%

3-butyl-4-ethoxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-ethox...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

3-butyl-4-ethoxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-ethox...

methyl 2-(N-phenylhexanamido)nicotinate结构式

methyl 2-(N-phe...

~%

3-butyl-4-ethoxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-ethox...

己酸乙酯结构式

methyl 2-((4-(methylthio)phenyl)amino)nicotinate结构式

methyl 2-((4-(m...

~80%

3-butyl-4-hydroxy-1-(4-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-氯烟酸结构式

~%

3-butyl-4-hydroxy-1-(4-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-(4-Methylsulfanyl-phenylamino)-nicotinic acid结构式

2-(4-Methylsulf...

~%

3-butyl-4-hydroxy-1-(4-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

4-氨基茴香硫醚结构式

4-氨基茴香硫醚

~%

3-butyl-4-hydroxy-1-(4-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-氯烟酸结构式

间氨基苯甲醚结构式

间氨基苯甲醚

~90%

2-(3-Methoxy-phenylamino)-nicotinic acid结构式

2-(3-Methoxy-ph...

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-溴乙醇结构式

~41%

3-butyl-4-(2-hydroxyethoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(2-hy...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

3-butyl-4-(2-hydroxyethoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(2-hy...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~%

3-butyl-4-(2-hydroxyethoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(2-hy...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

3-butyl-4-(2-hydroxyethoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(2-hy...

methyl 2-(N-phenylhexanamido)nicotinate结构式

methyl 2-(N-phe...

~%

3-butyl-4-(2-hydroxyethoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(2-hy...

己酸乙酯结构式

methyl 2-(3-methylsulfanylanilino)pyridine-3-carboxylate结构式

methyl 2-(3-met...

~87%

3-butyl-4-hydroxy-1-(3-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-氯烟酸结构式

~%

3-butyl-4-hydroxy-1-(3-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

3-氨基茴香硫醚结构式

3-氨基茴香硫醚

~%

3-butyl-4-hydroxy-1-(3-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-(3-Methylsulfanyl-phenylamino)-nicotinic acid结构式

2-(3-Methylsulf...

~%

3-butyl-4-hydroxy-1-(3-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

cyanomethyl 2-(3-methylthiophenylamino)nicotinate结构式

cyanomethyl 2-(...

~%

3-butyl-4-hydroxy-1-(3-methylsulfanylphenyl)-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-氯烟酸结构式

4-氟苯胺结构式

~90%

2-(4-Fluoro-phenylamino)-nicotinic acid结构式

2-(4-Fluoro-phe...

烯丙基溴结构式

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

~26%

3-butyl-1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

3-butyl-1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~%

3-butyl-1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

3-butyl-1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

methyl 2-(N-phenylhexanamido)nicotinate结构式

methyl 2-(N-phe...

~%

3-butyl-1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

3-butyl-1-pheny...

2-(N-acetylanilino)-3-carbomethoxypyridine结构式

2-(N-acetylanil...

~93%

4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~%

4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

3-溴-1-丙醇结构式

~88%

3-butyl-4-(3-hydroxypropoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(3-hy...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

3-butyl-4-(3-hydroxypropoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(3-hy...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~%

3-butyl-4-(3-hydroxypropoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(3-hy...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

3-butyl-4-(3-hydroxypropoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(3-hy...

methyl 2-(N-phenylhexanamido)nicotinate结构式

methyl 2-(N-phe...

~%

3-butyl-4-(3-hydroxypropoxy)-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-(3-hy...

4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

烯丙基溴结构式

~46%

1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

1-phenyl-4-prop...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

1-phenyl-4-prop...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~%

1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

1-phenyl-4-prop...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

1-phenyl-4-prop...

2-(N-acetylanilino)-3-carbomethoxypyridine结构式

2-(N-acetylanil...

~%

1-phenyl-4-prop-2-enoxy-1,8-naphthyridin-2-one结构式

1-phenyl-4-prop...

3-环己基丙酸乙酯结构式

3-环己基丙酸乙酯

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~76%

3-(cyclohexylmethyl)-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-(cyclohexylme...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

3-(cyclohexylmethyl)-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-(cyclohexylme...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

3-(cyclohexylmethyl)-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-(cyclohexylme...

2-(3-ethoxycarbonylpropyl)pyridine结构式

2-(3-ethoxycarb...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~86%

4-hydroxy-1-phenyl-3-(2-pyridin-2-ylethyl)-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

4-hydroxy-1-phenyl-3-(2-pyridin-2-ylethyl)-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

4-hydroxy-1-phenyl-3-(2-pyridin-2-ylethyl)-1,8-naphthyridin-2-one结构式

4-hydroxy-1-phe...

己酸乙酯结构式

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~82%

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-氯烟酸甲酯结构式

2-氯烟酸甲酯

~%

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

methyl 2-(N-phenylhexanamido)nicotinate结构式

methyl 2-(N-phe...

~%

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...

2-苯基氨基烟酸甲酯结构式

2-苯基氨基烟酸甲酯

~%

3-butyl-4-hydroxy-1-phenyl-1,8-naphthyridin-2-one结构式

3-butyl-4-hydro...