Study of kaempferol glycoside as an insulin mimic reveals glycon to be the key active structure

K Yamasaki, R Hishiki, E Kato…

文献索引：Yamasaki, Kazuaki; Hishiki, Ryogo; Kato, Eisuke; Kawabata, Jun ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 17 - 21

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被引用次数: 19

摘要

Diabetes mellitus is increasing in prevalence with patient numbers rising throughout the world. Current treatments for diabetes mellitus focus on control of blood glucose levels. Certain kinds of flavonoids or their glycosides stimulate cells to improve glucose uptake and lower blood glucose levels. We synthesized kaempferol 3-O-neohesperidoside (1), a naturally occurring substance present in Cyathea phalerata Mart., reported to mimic the ...