Microbial metabolism of biologically active secondary metabolites from Nerium oleander L.

A Ibrahim, SI Khalifa, I Khafagi, DT Youssef…

文献索引：Ibrahim, Amany; Khalifa, Sherief Ibrahim; Khafagi, Ishrak; Youssef, Diaa Tohamy; Khan, Shabana; Mesbah, Mostafa; Khan, Ikhlas Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 9 p. 1253 - 1258

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被引用次数: 25

摘要

Ursolic acid (1) and kaempferol (3) are two major constituents of the Mediterranean plant Nerium oleander L. Microbial metabolism of (1) with Aspergillus flavus (ATCC 9170) resulted in the formation of 3-oxo-ursolic acid derivative, ursonic acid (2). On the other hand, Cunninghamella blakesleeana (ATCC 8688A) was able to convert (3) into kaempferol 3-O-β- D-glucopyranoside (4) as well as the new natural product kaempferol 4′-sulfate (5). ...