Synthesis and biological evaluation of benzo [b] furans as inhibitors of tubulin polymerization and inducers of apoptosis

…, V Srinivasulu, M Vishnuvardhan, CS Reddy

文献索引：Kamal, Ahmed; Reddy, N. V. Subba; Nayak, V. Lakshma; Reddy, V. Saidi; Prasad; Nimbarte, Vijaykumar D.; Srinivasulu, Vunnam; Vishnuvardhan; Reddy, C. Suresh ChemMedChem, 2014 , vol. 9, # 1 p. 117 - 128

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被引用次数: 16

摘要

Abstract A series of benzo [b] furans was synthesized with modification at the 5-position of the benzene ring by introducing C-linked substituents (aryl, alkenyl, alkynyl, etc.). These compounds were evaluated for their antiproliferative activities, inhibition of tubulin polymerization, and cell-cycle effects. Some compounds in this series displayed excellent activity in the nanomolar range against lung cancer (A549) and renal cell carcinoma ( ...