Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase …

MH David-Cordonnier, MP Hildebrand…

文献索引：David-Cordonnier, Marie-Helene; Hildebrand, Marie-Paule; Baldeyrou, Brigitte; Lansiaux, Amelie; Keuser, Christoph; Benzschawel, Kerstin; Lemster, Thomas; Pindur, Ulf European Journal of Medicinal Chemistry, 2007 , vol. 42, # 6 p. 752 - 771

全文：HTML全文

被引用次数: 39

摘要

In the context of the design and synthesis of minor groove binding and intercalating DNA ligands some new oligopyrrole carboxamides were synthesized. These hybrid molecules (combilexins) possess a variable and conformatively flexible spacer at the N-terminal end. As intercalating tricyclic systems acridone, acridine, anthraquinones and in a special case iminostilbene terminate the N-terminal end of the pyrrole chain. The cytotoxicity was ...