FEBS Journal

Benzimidazole analogs of l??tryptophan are substrates and inhibitors of tryptophan indole lyase from Escherichia coli

AP Harris, RS Phillips

文献索引：Harris, Austin P.; Phillips, Robert S. FEBS Journal, 2013 , vol. 280, # 8 p. 1807 - 1817

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被引用次数: 1

摘要

Abstract Tryptophan indole lyase (TIL), an enzyme found in Escherichia coli and related enterobacteria, produces indole from l-tryptophan (l-Trp). Indole is a signaling molecule in bacteria, affecting biofilm formation, pathogenicity and antibiotic resistance. β-(Benzimidazol- 1-yl)-l-alanine (BZI-Ala), 2-amino-4-(benzimidazol-1-yl) butyric acid (homo-BZI-Ala) and 2- amino-5-(benzimidazol-1-yl) pentanoic acid (bishomo-BZI-Ala) were synthesized and ...