Tetrahedron

An efficient one-pot synthesis of 6-alkoxy-8, 9-dialkylpurines via reaction of 5-amino-4-chloro-6-alkylaminopyrimidines with N, N-dimethylalkaneamides and alkoxide …

…, MJP de las Infantas, JJD Mochun, A Espinosa…

文献索引：Baraldi, Pier Giovanni; Broceta, Asier Unciti; Infantas, Maria Jose Pineda De Las; Mochun, Juan Jose Diaz; Espinosa, Antonio; Romagnoli, Romeo Tetrahedron, 2002 , vol. 58, # 38 p. 7607 - 7611

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被引用次数: 19

摘要

The synthesis of a number of new 6-alkoxy-8, 9-(disubstituted) purines has been accomplished by the cyclization of the corresponding intermediate 5-amino-4-chloro-6- (alkylamino) pyrimidines promoted by alkoxides and various N, N-dimethyl amides, where the latter act as solvent–reagents. By this three-component condensation reaction we are able to introduce an alkyl group in the 8 position of the purine ring with the concomitant ...