European journal of medicinal chemistry

Design, synthesis, DNA-binding and cytotoxicity evaluation of new potential combilexines

C Hotzel, A Marotto, U Pindur

文献索引：Hotzel, Christian; Marotto, Annalisa; Pindur, Ulf European Journal of Medicinal Chemistry, 2002 , vol. 37, # 5 p. 367 - 378

全文：HTML全文

被引用次数: 16

摘要

Combilexines, compounds in which a DNA intercalator is linked to a minor groove binding component, interact with the DNA in a sequence specific manner to yield in most cases compounds with anticancer activity. A series of new compounds closely related to netropsin in which the two components were linked by an amide group was synthesised as potential combilexines. As some of these compounds showed cytotoxic activity in vitro, an attempt ...